N2Jenomics Lab Pvt. Ltd. offers comprehensive DNA methylation microarray services, delivering robust and high-resolution methylation profiling with extensive coverage of CpG islands, gene regions, promoters, enhancers, and other key regulatory elements across the genome.
DNA methylation is a critical epigenetic modification that regulates gene expression without altering the underlying DNA sequence. It plays a fundamental role in normal growth and development and is involved in numerous biological processes, including genomic imprinting, X-chromosome inactivation, suppression of repetitive DNA elements, cellular differentiation, aging, and cancer development. Changes in DNA methylation patterns have also been linked to a wide range of complex diseases and environmental influences, making methylation analysis an indispensable tool for modern biomedical research.
Leveraging industry-leading and extensively validated DNA methylation microarray platforms, N2Jenomics Lab Pvt. Ltd. provides accurate, reproducible, and high-throughput methylation profiling solutions for epigenome-wide association studies (EWAS). Our services combine expert-curated genomic coverage with scalable workflows, enabling reliable analysis of large sample cohorts while generating high-quality data for biomarker discovery, disease research, and translational studies.
Table 1. Available DNA methylation microarray
| Microarray Platform | Species | Coverage | Technology Provider |
|---|---|---|---|
| Infinium™ MethylationEPIC v2.0 (935K) Array | Human | Profiles over 935,000 CpG sites with comprehensive coverage of CpG islands, promoters, enhancers, gene bodies, and regulatory regions across the human methylome. | Illumina |
| Infinium™ MethylationEPIC (850K) Array | Human | Measures 850,000+ CpG methylation sites at single-nucleotide resolution for genome-wide DNA methylation analysis. | Illumina |
| Human CpG Island Microarray | Human | Covers approximately 27,800 CpG islands spanning nearly 21 Mb of the human genome. | Agilent |
| Human DNA Methylation Microarray | Human | Targets 27,627 expanded CpG islands and 5,081 unmethylated regions (UMRs) for comprehensive methylation profiling. | Agilent |
| Mouse CpG Island Microarray | Mouse | Profiles 15,342 CpG islands for genome-wide mouse DNA methylation studies. | Agilent |
| Infinium™ Methylation Screening Array (MSA 270K) | Human | Covers approximately 270,000 strategically selected CpG sites optimized for disease cohort studies, population-scale research, and large health screening programs. Supports 48 samples per BeadChip, delivering 6× higher throughput than the Infinium MethylationEPIC v2.0 Array while significantly reducing cost per sample without compromising analytical performance. | Illumina |
This Agilent Methylation Assay protocol describes the use of methylation microarrays for the analysis of Methylated DNA Immunoprecipitation (MeDIP).
The Illumina Infinium Methylation Assay Protocol combines bisulfite conversion of genomic DNA and whole-genome amplification (WGA) with direct, array-based capture and scoring of the CpG loci.
Our Full Service covers the complete process, from quality control of the samples to final data analysis. Besides, N2Jenomics Lab Pvt. Ltd. can also help create your custom microarray which can be tailored to meet specific project requirements. If you have additional requirements or questions, please feel free to contact us.